RT期刊文章SR电子T1 thrombophilic风险因素的作用在肺血栓栓塞的严重程度摩根富林明欧洲呼吸杂志乔和J FD欧洲呼吸学会SP 709欧元OP 711 10.1183 / 09031936.02.01472001 VO 19是4 A1 I.K. Oguzulgen A1 N.N. Ekim A1 n Akar A1 K。188bet官网地址德米雷尔A1 m . Kitapci年2002 UL //www.qdcxjkg.com/content/19/4/709.abstract AB等离子factor-VIIIc浓度高,地理因素所致的V 1691 G (FVL)和prothrombin20210A (PT20210A)突变被证明是重要的静脉血栓栓塞的危险因素和复发性静脉血栓栓塞(VTE)。本研究的目的是调查这些血栓形成的危险因素的作用在肺动脉血栓栓塞(PTE)的严重程度。VIIIc血浆浓度的因素,FVL和PT20210A突变在32 PTE患者。研究了11个病人有记录的复发性静脉血栓栓塞。肺灌注扫描是得分根据血管阻塞的百分比。患者肺血管阻塞评分(PVOs) > 50%相比PVOs < 50%。没有显著区别PVOs > 50%的患者和那些PVOs < 50%,关于FVL和PT20210A突变。然而,患者PVOs > 50% factor-VIIIc浓度明显高于那些PVOs < 50% (factor-VIIIc水平分别为253.3±29.1国际单位(IU)·dL−1和138.5±16.2 IU·dL−1,分别;p < 0.005)。与PVOs Factor-VIIIc浓度显著相关(r = 0.52, p < 0.005)。 Patients with recurrent VTE had significantly higher factor-VIIIc concentrations than those in which it occurred for the first time (factor-VIIIc concentrations were 232.6±30.9 IU·dL−1 and 158.3±20.6 IU·dL−1, respectively; p<0.05). The authors conclude that in addition to being a risk factor for venous thromboembolism, high factor-VIIIc concentration is an important factor in the severity of pulmonary thromboembolism.