Ty-Jour T1 - 呼吸道合胞病毒和随后的哮喘：解开戈尔迪结的一步更接近？JF - 欧洲呼吸杂志JO - EUR呼吸杂志SP - 515 LP - 517 DO - 10.1183 / 09031936.02.00404602 VL - 20 - 3 AU - Piedimonte，G. AU - 西蒙斯，E.A.F.Y1 - 2002年9月1日UR - //www.qdcxjkg.com/content/20/3/515.abstract N2 - 呼吸道合胞病毒（RSV）是婴儿期最常见的呼吸道病原体，感染范围内几乎所有的孩子前2年的生命1.越来越多的证据表明，生命早期严重的RSV降低呼吸道感染（LRI）是在后期童年期间发作经常发作喘息和哮喘的重要危险因素2，但该领域与明显争议3-13。最近从亚利桑那州的图森儿童呼吸研究的一篇论文已经证明，在前3年的前3岁的生活中，温和至温和的RSV LRI是随后喘息7,8岁的重要风险因素，最多11年，但这风险不再有统计学意义13年龄。在这项研究中，没有任何关系，无感染和Atopate的发育。In contrast, in Boras, Sweden, subsequent recurrent wheezing in later childhood (up to 7 yrs of follow-up) was observed in children with a history of severe bronchiolitis requiring hospitalisation in infancy 9, 10 and a significant association was found between RSV and atopic sensitisation, which was not explained by a family history of asthma or atopy. How does one reconcile these apparently discrepant observations? Clearly not all children with recurrent wheezing disease have been previously hospitalised with severe RSV bronchiolitis and not all children with RSV LRI go on to wheeze. The explanation for these observations is slowly unravelling. It was initially suggested that RSV-specific immunoglobulin (Ig) E during acute infection and convalescence correlated with both the severity of RSV illness and subsequent wheezing 14. This implied that the immune responses to RSV were implicit in the subsequent development of an asthmatic phenotype, and has in part driven some of the studies examining the relationship between RSV infection and the T-helper (Th) 2-type responses to … ER -