TY -的T1 oxygen-sens分子生理学itive potassium channels JF - European Respiratory Journal JO - Eur Respir J SP - 221 LP - 227 VL - 18 IS - 1 AU - Patel, A.J. AU - Honoré, E. Y1 - 2001/07/01 UR - //www.qdcxjkg.com/content/18/1/221.abstract N2 - Physiological adaptation to acute hypoxia involves oxygen-sensing by a variety of specialized cells including carotid body type I cells, pulmonary neuroepithelial body cells, pulmonary artery myocytes and foetal adrenomedullary chromaffin cells. Hypoxia induces depolarization by closing a specific set of potassium channels and triggers cellular responses. Molecular biology strategies have recently allowed the identification of the K+ channel subunits expressed in these specialized cells. Several voltage-gated K+ channel subunits comprising six transmembrane segments and a single pore domain (Kv1.2, Kv1.5, Kv2.1, Kv3.1, Kv3.3, Kv4.2 and Kv9.3) are reversibly blocked by hypoxia when expressed in heterologous expression systems. Additionally, the background K+ channel subunit TASK-1, which comprises four transmembrane segments and two pore domains, is also involved in both oxygen- and acid-sensing in peripheral chemoreceptors. Progress is currently being made to identify the oxygen sensors. Regulatory β subunits may play an important role in the modulation of Kv channel subunits by oxygen. This work was supported by the Centre National de la Recherche Scientifique (CNRS). ER -