TY -的T1 -热事件在早期的生活和发展同哮喘儿童异位性的JF -欧洲呼吸杂志》乔欧元和J SP - 391 LP - 396 - 10.1183 / 09031936.02.00274502六世- 20 - 2非盟Calvani m . AU - Alessandri c . AU - BonciE. Y1 - 2002/08/01 UR - //www.qdcxjkg.com/content/20/2/391.abstract N2 -卫生假说提出，减少接触感染可能导致过敏和哮喘“流行”，但迄今为止，确定涉及感染的研究提供了相互矛盾的数据。另一种方法可能是基于尝试识别几种不同感染的共同机制，这可能会发挥特异反应的“保护”作用。其中一个机制可能是发烧，这通常与感染有关，并可能刺激干扰素- γ的合成。这项研究的目的是测试在生命最初几年发烧发作的频率是否与特应性疾病的发展有关。在过敏门诊就诊的哮喘患儿(317例)和非哮喘患儿(对照组304例)被纳入研究。父母通过问卷调查的方式对出生后2年发热次数进行回顾性评估。在检查时，通过皮肤点刺试验对10种常见的吸入性过敏原进行了特应性测定。在患有哮喘的儿童中，在生命的第一年或第二年出现发热发作的频率明显更高。然而，这种差异完全是由一组在出生后12个月就开始喘息的儿童造成的。 A significant inverse association between fever episodes in the first 12 months of life and atopy was found among cases, but not in controls. The association persisted after adjusting for age, sex, daycare attendance and family history of atopic disease and this was totally accounted for by asthmatic children who started wheezing after the first 12 months of life. No significant association was found between fever episodes in the second year of life and atopy for cases and controls. The data presented here suggests that fever episodes early in life may affect the natural history of asthma by preventing the development of atopy and highlights the need to monitor fever episodes of any kind in longitudinal studies aimed at investigating the hygiene hypothesis prospectively. ER -