ty -jour t1-早期生命中的发烧发作和患有JF儿童的特应发展 - 欧洲呼吸杂志Calvani，M.Au -Alessandri，C。au -Bonci，E。Y1-2002/08/01 Ur -http：//www.qdcxjkg.com/content.com/content/20/2/2/391.abstract N2-暴露于感染的下降可能会导致过敏和哮喘“流行病”，但是鉴定涉及的感染的研究到目前为止提供了相互矛盾的数据。另一种方法可能是基于尝试确定几种不同感染的机制，这些机制可能发挥特应当的“保护性”作用。这些机制之一可能是发烧，通常与感染有关，并可能刺激干扰素-γ的合成。这项研究的目的是测试生命初期发烧发作的频率是否与特应发展有关。哮喘（病例，n = 317）和非哮喘儿童（对照，n = 304）参加了门诊患者的过敏诊所。通过访谈完成的问卷调查表，通过父母报告回顾性评估了生命前两年的发烧发作数量。在检查时，通过对10种普遍吸入过敏原的皮肤化测试确定了应变。哮喘儿童的第一年或第二年，发烧发作的频率明显更高。 However, this difference was totally accounted for by a subgroup of children who started wheezing in the first 12 months of life. A significant inverse association between fever episodes in the first 12 months of life and atopy was found among cases, but not in controls. The association persisted after adjusting for age, sex, daycare attendance and family history of atopic disease and this was totally accounted for by asthmatic children who started wheezing after the first 12 months of life. No significant association was found between fever episodes in the second year of life and atopy for cases and controls. The data presented here suggests that fever episodes early in life may affect the natural history of asthma by preventing the development of atopy and highlights the need to monitor fever episodes of any kind in longitudinal studies aimed at investigating the hygiene hypothesis prospectively. ER -