Ty-Jour T1 - 发热剧集在早期生命和哮喘患儿儿童的开发 - 欧洲呼吸杂志Jo - Eur Respir J SP - 391 LP - 396 Do - 10.1183 / 09031936.02.00274502 VL - 20是 - 2 AU -Calvani，M. Au - Alessandri，C. Au - Bonci，E. Y1 - 2002/08/01 Ur - //www.qdcxjkg.com/content/20/2/391.abstract n2 - 卫生假设提议感染暴露可能导致过敏和哮喘的“疫情”，但迄今为止识别所涉感染的研究提供了促进的数据。另一种方法可以基于试图识别几种不同感染的机制，这可能施加特性“保护性”效果。这些机制之一可能是发烧，其通常与感染有关，并且可以刺激干扰素-γ的合成。本研究的目的是测试生命的第一年的发热频率是否与Atopate的发育有关。参加了参加门诊患者过敏诊所的哮喘（病例，N = 317）和非发育儿童（对照，N = 304）。通过采访完成的调查问卷，父母报告回顾性评估了前2年的前2年的发热剧集数。在检查时，通过皮肤刺刺的试验测定了Atace。在哮喘的儿童中，第一年或第二年生命中的发热剧集显着频繁。 However, this difference was totally accounted for by a subgroup of children who started wheezing in the first 12 months of life. A significant inverse association between fever episodes in the first 12 months of life and atopy was found among cases, but not in controls. The association persisted after adjusting for age, sex, daycare attendance and family history of atopic disease and this was totally accounted for by asthmatic children who started wheezing after the first 12 months of life. No significant association was found between fever episodes in the second year of life and atopy for cases and controls. The data presented here suggests that fever episodes early in life may affect the natural history of asthma by preventing the development of atopy and highlights the need to monitor fever episodes of any kind in longitudinal studies aimed at investigating the hygiene hypothesis prospectively. ER -