作者@article {Calvani391 = {Calvani, m . Alessandri, c和Bonci大肠},title ={热事件在早期生活和特异反应性的发展在儿童哮喘},体积={20}={2},页面= {391 - 396}= {2002},doi ={10.1183 / 09031936.02.00274502},出版商={欧洲呼吸学会},188bet官网地址卫生假说认为，减少接触感染可能会导致过敏和哮喘的流行，但迄今为止，确定相关感染的研究提供了相互矛盾的数据。另一种方法可能是基于尝试识别几种不同感染的共同机制，这可能会产生特异反应保护效应。其中一个机制可能是发热，它经常与感染有关，可能刺激干扰素-γ的合成。这项研究的目的是测试在生命最初几年发烧发作的频率是否与特应性疾病的发展有关。在过敏门诊就诊的哮喘患儿(317例)和非哮喘患儿(对照组，304例)被纳入研究。父母通过问卷调查的方式对出生后2年发热次数进行回顾性评估。在检查时，通过皮肤点刺试验对10种常见的吸入性过敏原进行了特应性测定。在患有哮喘的儿童中，在生命的第一年或第二年出现发热发作的频率明显更高。然而，这种差异完全是由一组在出生后12个月就开始喘息的儿童造成的。 A significant inverse association between fever episodes in the first 12 months of life and atopy was found among cases, but not in controls. The association persisted after adjusting for age, sex, daycare attendance and family history of atopic disease and this was totally accounted for by asthmatic children who started wheezing after the first 12 months of life. No significant association was found between fever episodes in the second year of life and atopy for cases and controls. The data presented here suggests that fever episodes early in life may affect the natural history of asthma by preventing the development of atopy and highlights the need to monitor fever episodes of any kind in longitudinal studies aimed at investigating the hygiene hypothesis prospectively.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/20/2/391}, eprint = {//www.qdcxjkg.com/content/20/2/391.full.pdf}, journal = {European Respiratory Journal} }