TY - JOUR T1 -甲氧孕酮在绝经后女性睡眠中出现部分上呼吸道阻塞JF -欧洲呼吸杂志JO - Eur Respir J SP - 989 LP - 995 DO - 10.1183/09031936.01.00099401 VL - 18 IS - 6 AU - Saaresranta, T. AU - Polo- kantola, P. AU - Rauhala, E. AU - Polo，本研究的目的是评估醋酸甲羟孕酮(MPA)对睡眠呼吸障碍的呼吸刺激程度和持续时间，并比较MPA与鼻持续气道正压(nCPAP)对睡眠呼吸障碍的影响。10名睡眠中出现部分上气道梗阻的绝经后女性在基线、MPA治疗的第14天和3周洗脱期后进行了夜间睡眠研究。3个月后对6名nCPAP受试者进行了研究。在基线时，二氧化碳(Pet,CO2)的夜间平均±标准差潮末压力为5.5±0.4 kPa，动脉氧饱和度(Sa,O2)为93.0±1.2%，Sa,O2的最低点为80.0±6.7%，氧饱和度小于或等于4% (ODI4)的频率为2.2±1.3。MPA降低Pet,CO2 0.8 kPa (14.5%， p<0.001)。冲洗后，平均Pet、CO2保持在比基线低0.5 kPa (9.1%， p<0.001)。Sa,O2没有变化。Pet、CO2在MPA下低于nCPAP(4.7±0.2 kPa vs 5.0±0.3 kPa;p=0.037)，而Sa、O2含量相近。 Apnoea/hypopnoea index tended to be lower on CPAP than on MPA. Medroxyprogesterone acetate at a daily dose of 60 mg improves ventilation in postmenopausal females with partial upper airway obstruction during sleep without compromising sleep. The ventilatory improvement is sustained for at least 3 weeks post-treatment. Medroxyprogesterone acetate was more efficient in decreasing the partial pressure of carbon dioxide but continuous positive airway pressure was superior in decreasing respiratory efforts. This work was supported by grants from the Finnish Sleep Research Society, The Finnish Anti-Tuberculosis Association Foundation, The Research Foundation for Pulmonary Diseases, The Väinö and Laina Kivi Foundation and The Turku University Foundation. O. Polo was supported by The Paulo Foundation. ER -