TY -的T1 -甲羟孕酮在绝经后女性部分睡眠期间上呼吸道阻塞JF -欧洲呼吸杂志》乔欧元和J SP - 989 LP - 995 - 10.1183 / 09031936.01.00099401六世——18 - 6盟Saaresranta t . AU - Polo-Kantola p . AU - Rauhala表示,e . AU -马球,o . Y1 - 2001/12/01 UR - //www.qdcxjkg.com/content/18/6/989.abstract N2 -本研究的目的是评估的程度和持续时间引起的呼吸道刺激甲孕酮(MPA),并比较MPA的鼻的效果持续正压通气(nCPAP)的睡眠呼吸障碍。10绝经后女性的主要部分在睡眠时上气道阻塞在基线,一夜睡眠研究的14天治疗与MPA和后三星期的洗脱期。六个科目nCPAP也学习了3个月后。在基线,一夜之间平均±sd end-tidal压力的二氧化碳(宠物,二氧化碳)为5.5±0.4 kPa动脉氧饱和度(Sa, O2) 93.0±1.2%, Sa O2最低点80.0±6.7%,血氧饱和度下降⩾4%和频率(ODI4)每小时2.2±1.3。MPA宠物减少,二氧化碳0.8 kPa(14.5%,术中;0.001)。冲刷后,意思是宠物,二氧化碳维持在0.5 kPa(9.1%,术中;0.001)低于基线。Sa, O2没有变化。宠物,MPA比nCPAP二氧化碳低(4.7±0.2 kPa和5.0±0.3 kPa;p = 0.037),但Sa, O2是相似的。呼吸暂停/ hypopnoea指数对CPAP往往低于MPA。 Medroxyprogesterone acetate at a daily dose of 60 mg improves ventilation in postmenopausal females with partial upper airway obstruction during sleep without compromising sleep. The ventilatory improvement is sustained for at least 3 weeks post-treatment. Medroxyprogesterone acetate was more efficient in decreasing the partial pressure of carbon dioxide but continuous positive airway pressure was superior in decreasing respiratory efforts. This work was supported by grants from the Finnish Sleep Research Society, The Finnish Anti-Tuberculosis Association Foundation, The Research Foundation for Pulmonary Diseases, The Väinö and Laina Kivi Foundation and The Turku University Foundation. O. Polo was supported by The Paulo Foundation. ER -