TY -的T1 -甲羟孕酮在绝经后女性部分睡眠期间上呼吸道阻塞JF -欧洲呼吸杂志》乔欧元和J SP - 989 LP - 995 - 10.1183 / 09031936.01.00099401六世——18 - 6盟Saaresranta t . AU - Polo-Kantola p . AU - Rauhala表示,e . AU -波罗o . Y1 - 2001/12/01 UR - //www.qdcxjkg.com/content/18/6/989.abstract N2 -本研究的目的是评估的程度和持续时间引起的呼吸道刺激甲孕酮(MPA),并比较MPA的鼻的效果持续正压通气(nCPAP)的睡眠呼吸障碍。10名绝经后女性在睡眠中出现主要部分上呼吸道阻塞，在服用MPA治疗的第14天和3周洗脱期后进行了夜间睡眠研究。3个月后，对6名nCPAP受试者进行了研究。在基线时，隔夜平均±sd二氧化碳呼气末压力(Pet,CO2)为5.5±0.4 kPa，动脉氧饱和度(Sa,O2) 93.0±1.2%，Sa,O2最低点80.0±6.7%，每小时氧去饱和频率小于或等于4% (ODI4) 2.2±1.3。MPA使Pet、CO2降低0.8 kPa (14.5%， p<0.001)。洗脱后，平均Pet、CO2保持在0.5 kPa (9.1%， p<0.001)低于基线。Sa,O2没有变化。Pet、CO2压力低于nCPAP(4.7±0.2 kPa vs 5.0±0.3 kPa;p=0.037)，而Sa、O2相似。 Apnoea/hypopnoea index tended to be lower on CPAP than on MPA. Medroxyprogesterone acetate at a daily dose of 60 mg improves ventilation in postmenopausal females with partial upper airway obstruction during sleep without compromising sleep. The ventilatory improvement is sustained for at least 3 weeks post-treatment. Medroxyprogesterone acetate was more efficient in decreasing the partial pressure of carbon dioxide but continuous positive airway pressure was superior in decreasing respiratory efforts. This work was supported by grants from the Finnish Sleep Research Society, The Finnish Anti-Tuberculosis Association Foundation, The Research Foundation for Pulmonary Diseases, The Väinö and Laina Kivi Foundation and The Turku University Foundation. O. Polo was supported by The Paulo Foundation. ER -