TY -的T1之间的关联标记欧洲儿童的呼吸道发病率摩根富林明-欧洲呼吸杂志》乔欧元和J SP - 479 LP - 486 - 10.1183 / 09031936.02.00087802六世- 19 - 3盟Timonen K.L. AU -施瓦茨,J . AU -尼尔森,J . AU - Brunekreef b Y1 - 2002/03/01 UR - //www.qdcxjkg.com/content/19/3/479.abstract N2 -学龄儿童经常出现急性呼吸道症状。在欧洲的一项多中心研究中，对6-12岁患有慢性呼吸道症状的儿童进行了慢性呼吸道症状(通过问卷报告)、皮肤点刺试验结果、肺功能和急性呼吸道疾病发生之间的关系进行了调查。来自10个欧洲国家的患有慢性呼吸道症状的儿童从家长填写的问卷中选取(n=4,307)。用皮肤点刺试验测量特异反应，用肺活量测定肺功能。共有1854名儿童(初始队列中86%的儿童)在2-3个月的时间里成功地每天记录他们的呼吸道症状。在多因素logistic回归分析中，有哮喘症状的儿童，特别是那些医生诊断为哮喘的儿童，发生下呼吸道症状的风险更大(优势比(OR): 6.12;95%可信区间(CI): 4.99 ~ 8.35)优于以夜间干咳为唯一症状的儿童。特异反应，特别是对室内过敏原的阳性反应，与下呼吸道症状的发生显著相关。对于特异反应，OR为1.62 (95% CI: 1.34-1.96)。最大呼气中流量水平降低与下呼吸道症状、咳嗽和痰的风险增加有关。 The associations were similar in Scandinavia, Central Eastern, Western and Southern Europe. To conclude, asthmatic symptoms reported in a questionnaire, atopic status and a reduced level of maximal mid-expiratory flow were associated with the occurrence of acute respiratory symptoms, especially those of lower respiratory symptoms. This study was funded in the framework of the Commission of the European Communities Environment Programme, contracts EV5V-CT92-0220, CIPD-CT-92-5052 and ERBCIPD-CT-93-0046. K.L. Timonen was supported by grants from The Finnish Anti-Tuberculosis Association Foundation and The Ida Montin Foundation. The Finnish, Norwegian and two Swedish centres were funded by grants from the respective Governments. ER -