TY - JOUR T1 - 在呼吸机相关肺炎JF关于保护样本毛刷采样抗生素对 - 欧洲呼吸杂志JO - EUR呼吸杂志SP - 944 LP - 951 DO - 10.1183 / 09031936.02.00239302 VL - 19 - 5 AU - 普拉斯，E. AU - Dorca，J. AU - 普霍尔，M. AU - 加西亚，L. AU - 巴雷罗，B. AU - VERDAGUER，R. AU - Gudiol，F. AU - 曼雷沙，F. Y1 - 2002/05/ 01 UR - //www.qdcxjkg.com/content/19/5/944.abstract N2 - 抗生素治疗的关于保护标本在呼吸机相关肺炎涂刷（PSB）的结果的影响进行前瞻性通过执行评估this procedure before antibiotic treatment, and 12, 24, 48 and 72 h after initiation of antibiotic treatment, in 35 ventilated patients who developed pneumonia during mechanical ventilation. The number of micro-organisms isolated, their concentration (colony-forming units (cfu)·mL−1), and the number of cases with a positive PSB (≥103 cfu·mL−1) were evaluated. Within 12 h of the initiation of effective antibiotic treatment a rapid, significant decrease in the numbers of organisms isolated, their individual concentrations and the percentage of positive PSB results were observed. Certain bacterial species (Streptococcus pneumoniae, Haemophilus influenzee) appeared to be more vulnerable to antibiotics than others (Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumanni). This data confirms that prior antibiotic treatment, even after only a few hours of activity, significantly decreases the sensitivity of protected brush specimen; this effect appears to be particularly marked among the species involved in early ventilator associated pneumonia. This study was supported by a grant awarded by the “Fondo de Investigaciones Sanitarias de la Seguridad Social” (FIS) No 94/0874. ER -