TY-JUR T1 - 诱导型一氧化氮合酶和黄嘌呤氧化酶抑制剂对小鼠急性肺炎群岛诱导的巨型氧化酶抑制剂的影响 - 欧洲呼吸期刊Jo - EUR RESPIR J SP - 447 LP - 457 DO - 10.1183 / 09031936.02.00265902 VL-19是- 3 AU - Miyakawa，H. Au - Sato，K. Au - Shinbori，T. Au - Okamoto，T. Au - Gustima，Y.Au - Fujiki，M. Au - Suga，M. Y1 - 2002/03 /01 UR - //www.qdcxjkg.com/content/19/3/447.abstract n2 - 此前据报道，腹腔内滴注的葡萄球菌肠毒素-b（seb）诱导自身免疫性肺炎（IP）诱导的间质性肺炎老鼠。SEB-反应性T细胞批判性地参与IP在该模型中的IP。对肺损伤和纤维化过程中的活性氧物质（ROS）和反应性氮物质（RNS）的危害产生了担忧。因此，研究了一氧化氮（NO）和超氧化物阴离子（O2-）在该自身免疫易于模型中IP的发病机制中的参与。支气管肺泡灌洗（BAL）流体和来自SEB注射小鼠的血清的亚硝酸盐/硝酸盐水平增加。通过电子顺磁共振（EPR）光谱在SEB注入的肺和全血中检测到NO-（N-（二硫羧酸）肌氨酸）2-Fe2 +复合物的信号。氨基胍（AG）治疗没有生产明显减少。 Xanthine oxidase (XO) activity in the lung, BAL fluid, and plasma was increased with instillation of SEB, and 4‐amino‐6‐hydroxypyrazolo(3,4‐d)‐pyrimidine (AHPP) significantly inhibited XO activity. Moreover, both AG and AHPP significantly decreased production of pro-inflammatory cytokines, numbers of infiltrated cells in BAL fluid, and the area of thickened alveolar septa in the SEB-injected lung. In conclusion, the overproduction of nitric oxide and super oxide anion were implicated in the pathogenesis of interstitial pneumonia, and inducible nitric oxide synthase and xanthine oxidase inhibitors had protective effects against interstitial pneumonia in this model. This work was supported by a grant-in-aid for interstitial lung disease from the Ministry of Health, Labour and Welfare, Japan. ER -