TY - JOUR T1 -男性低氧性肺动脉高压:低氧血症的最低每日持续时间是多少?JF -欧洲呼吸杂志》乔和J SP - 251 LP - 253欧元六世- 18 - 2非盟Weitzenblum e . AU - Chaouat a Y1 - 2001/08/01 UR - //www.qdcxjkg.com/content/18/2/251.abstract N2 -这是认识到慢性肺泡缺氧肺动脉高压的主要原因是慢性呼吸道疾病1。因此，这种形式的继发性肺动脉高压通常被称为缺氧性肺动脉高压。肺泡缺氧的急性影响(缺氧血管收缩)实际上必须与长期影响(肺血管“重塑”)区分开来，这两种影响都会增加肺血管阻力和肺动脉压力。低氧血症的阈值是55-60 mmHg，即发生肺动脉高压(PAH)的风险升高，相当于氧饱和度为88-90%。这一水平通常是需要长期氧疗的患者需要的2-4。在慢性呼吸系统疾病，特别是慢性阻塞性肺病(COPD)中，低氧血症通常是永久性的，在白天和夜间都可以观察到。事实上，它会受到波动的影响，在运动(如散步)和睡眠期间，低氧血症可能会恶化。在阻塞性睡眠呼吸暂停综合征(OSAS)这一特定疾病中，低氧血症可能仅限于夜间，即睡眠。这种睡眠相关性低氧血症也可以在日间低氧血症尚未出现的慢性呼吸系统疾病的早期阶段观察到，如COPD 5、囊性纤维化和限制性肺病。 This has raised the question: can isolated nocturnal hypoxaemia induce pulmonary hypertension in humans? In other terms, what minimum daily duration of hypoxaemia is required to generate permanent (night-time and daytime) pulmonary hypertension? Apart from its theoretical interest, the answer to this question may have some practical importance. As an example, if it is demonstrated that COPD patients without significant daytime hypoxaemia (arterial oxygen tension (Pa,O2) >60 mmHg) but with sleep-related hypoxaemia, develop pulmonary hypertension, it will be justified to prescribe them nocturnal oxygen therapy. At the present time it is not known … ER -