TY - T1的支气管炎症的急性细菌性急性加重慢性支气管炎:白三烯B4摩根富林明的角色——欧洲呼吸杂志》乔和J SP - 274 LP - 280欧元六世- 15 - 2非盟骗子SW AU -贝利,DL AU -希尔,SL盟——Stockley RA Y1 - 2000/02/01 UR - //www.qdcxjkg.com/content/15/2/274.abstract N2 -中性粒细胞招募气道慢性阻塞性肺疾病(COPD)被认为调解组织的破坏。嗜中性粒细胞补充在细菌恶化期间增加。研究慢性阻塞性肺病急性加重患者的炎症过程，以确定白三烯B4 (LTB4)的作用。对8例慢性阻塞性肺病细菌性加重患者的痰中进行中性粒细胞产物(髓过氧化物酶，弹性酶)和趋化剂(白细胞介素-8 (IL-8)和LTB4)分析。使用LTB4受体拮抗剂LY293111测定LTB4对痰液期趋化活性的贡献。测定血清急性期蛋白- 1-蛋白酶抑制剂、- 1-抗胰凝乳蛋白酶和c反应蛋白的浓度。所有患者接受了7-14天的适当广谱抗生素治疗。最初，痰中髓过氧化物酶活性高，提示中性粒细胞内流;这与高水平的IL-8和LTB4有关。所有这些浓度在处理后均下降(p<0.01)。 The chemotactic activity of the sputum was raised on presentation and fell with treatment (p<0.01). LTB4 contributed approximately 30% of the total chemotactic activity on presentation; this diminished with therapy. All acute phase proteins were raised on presentation and fell with therapy (p<0.01). These findings suggest that leukotriene B4 contributes to neutrophil influx into the airway in chronic obstructive pulmonary disease and may influence disease progression. ER -