@article {gelb928，作者= {gelb，af和mckenna，rj和布伦纳，M和fischel，r and r and zamel，n}，title = {双侧下叶后肺部功能减少alpha1- antitrypsin insalpha1- antitrypsin emphysema}，体积}，体积= {14}，number = {4}，页面= {928--933}，ear = {1999}，publisher = {欧洲呼吸社会}，摘188bet官网地址要= {本研究探索了肺后气流限制的机制（s）由于纯合α1-抗抑制蛋白蛋白（AT）缺乏，肺气肿患者的体积减少手术（LVR）。使用视频胸腔镜检查进行双侧靶向下叶的LVR，对61名患者（男性）61 +/- 9年（平均值+/- SD）进行α1-AT肺气肿进行。两名患者仅接受6个月的随访。然而，LVR后22、24、27和36个月的四名患者指出，呼吸困难并增加了步行耐受性。在LVRS后27 +/- 6个月（平均+/- SD），其强迫呼气量仅从30 +/- 2 \％的预测值（平均值+/- SEM）提高到手术前的33+/手术后-1 \％pred。然而，总肺容量（TLC）从151 +/- 13降至127 +/- 10 \％pred;扩散能力从35 +/- 9增加到59 +/- 9 \％pred;生命力从68 +/- 10增加到88 +/- 5 \％pred。 In three patients, static lung elastic recoil at TLC increased from 1.1+/-0.15 to 1.2+/-0.10 kPa. Using flow/pressure curves, the mechanism for expiratory airflow limitation pre-LVRS and the improvement noted post-LVRS could be primarily accounted for by the initial loss and subsequent increase in lung elastic recoil. Bilateral lung volume reduction surgery provides modest physiologic improvement for 2-3 yrs in patients with alpha1-antitrypsin emphysema due to increases in lung elastic recoil.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/14/4/928}, eprint = {//www.qdcxjkg.com/content/14/4/928.full.pdf}, journal = {European Respiratory Journal} }