TY - JOUR T1 -慢性支气管炎下气道细菌定植的危险因素JF -欧洲呼吸杂志JO - Eur Respir J SP - 338 LP - 342 VL - 13 IS - 2 AU - Monso, E AU - Rosell, A AU - Bonet, G AU - Manterola, J AU - Cardona, PJ AU - Ruiz, J AU - Morera，本研究的目的是确定稳定型慢性支气管炎(CB)患者下气道细菌定植(LABC)的患病率和危险因素。41名CB门诊患者被纳入研究(年龄63.8+/-9.1岁(平均+/-SD);一秒用力呼气量(FEV1)/用力肺活量(FVC) 62.8±11.2;目前/以前的吸烟者24/17)。所有患者胸片正常，并有进行纤维支气管镜检查的指征(肺结节，远端咯血)。采用保护标本刷(PSB)进行细菌取样，浓度>or = 1,000菌落形成单位(cfu) x mL(-1)为LABC阳性。在18名受试者的随机子样本中评估了CB中程序的可重复性。在PSB技术的重复性评价中，有72.2%的定量一致性。 Positive PSB cultures, obtained in 9 out of 41 (22%) patients, mainly yielded Haemophilus influenzae. The logistic regression model, used to determine which variables were related to colonization, showed that LABC was associated with current smoking (odds ratio (OR) 9.83, confidence interval (CI) 1.16-83.20) and low FVC (OR 0.73, CI 0.65-0.81). Age and FEV1 were not related to LABC. It was concluded that the prevalence of LABC in stable CB is high (22%), and current smoking is an important risk factor. ER -