RT杂志文章SR电子T1运动诱发支气管收缩的严重程度与哮喘患者气道嗜酸性炎症相关JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 879 OP 884 DO 10.1183/09031936.98.12040879 VO 12 is 4 A1 Yoshikawa, T A1 Shoji, S A1 Fujii, T A1 Kanazawa, H A1 Kudoh, S A1 Hirata, 188bet官网地址K A1 Yoshikawa，运动诱发支气管收缩(EIB)在哮喘患者中广泛存在。嗜酸性气道炎症被认为是哮喘发病的一个主要因素。然而，嗜酸性气道炎症对EIB的影响尚不清楚。为探讨EIB的严重程度与嗜酸性炎症的关系，对21例哮喘患者进行了痰诱导和运动挑战。eib阳性哮喘患者诱导痰中嗜酸性粒细胞百分比和嗜酸性阳离子蛋白(ECP)水平明显升高(中位数(范围)，嗜酸性粒细胞:23.5 (11.0-61.0)%;ECP: 1475 (74.8- 17701) ng x mL(-1))比eib阴性哮喘患者(嗜酸性粒细胞:6.0 (1.0-41.5)% (p=0.006);ECP: 270.6 (10.8-7,700) ng x mL(-1) (p=0.049)。EIB的严重程度与痰中嗜酸性粒细胞百分比相关(r=0.59, p=0.009)， ECP水平相关(r=0.47, p=0.037)。运动后30min 1秒用力呼气量曲线下面积与嗜酸性粒细胞百分比(r=0.60, p=0.008)和ECP水平相关(r=0.45, p=0.04)。 There was no correlation between airway responsiveness to methacholine on the one hand and EIB, sputum eosinophils or ECP on the other. In conclusion, these results provide evidence that the severity of bronchoconstriction evoked by exercise is more closely related to eosinophilic airway inflammation than airway hyperresponsiveness to methacholine in asthmatic patients.