@Article {Hayes946,作者= {海耶斯,Rd和海滩,JR和Rutherford,DM和SIM,MR},标题= {甲基氯酰氯溶液在不同储存条件下的9个月期间},体积= {11},Number = {4},页面= {946--948},年= {1998},出版商= {欧洲呼吸社会},摘要= {甲胆碱氯化188bet官网地址物溶液,常规用于测试支气管过度反应性,已被证明会随着时间的推移而降低。发布的数据出版了甲胆碱氯化物储存的最佳条件是冲突和不完整的。本研究研究了各种条件对氯化甲甲氯化物稳定性的影响。在50和0.39g×L(-1)下溶解在磷酸盐缓冲盐水(PBS)或氯化钠(NaCl)中的甲胆碱,进行各种光和温度条件9个月。通过高效液相色谱法测定甲胆碱氯化物降解,以及所有溶液接受细菌和pH检测。通过9个月,所有50g x l(-1)氯化甲酰氯的溶液均可降解65 +/- 0.8 \%。NaCl的所有0.39g x L(-1)溶液溶液降解11.0 +/- 0.33 \%。在室温下冷冻或储存的PBS中的0.39g x L(-1)溶液分别降解了8.0×%,16.0 +/- 0.3 \%和63.8 +/- 0.5 \%。甲胆碱的pH为0.39g×L(-1),50g×L(-1),3.9的PBS的PB为0.39g×L(-1),3.9,在NaCl为0.39和2.7,在50g×L(-1)。 Bacterial contamination was minimal. The results of this study demonstrate that methacholine chloride is more stable at the higher concentration. However, the pH of the more concentrated solutions of methacholine chloride in sodium chloride could cause bronchoconstriction in some subjects. We therefore recommend storing methacholine chloride at 50 g x L(-1) in phosphate-buffered saline.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/11/4/946}, eprint = {//www.qdcxjkg.com/content/11/4/946.full.pdf}, journal = {European Respiratory Journal} }