RT期刊文章SR电子T1的影响反复猪建筑曝光正常的幼稚的话题摩根富林明欧洲呼吸杂志乔和J FD欧洲呼吸学会SP 1516欧元OP 1522签证官10 7 A1 Cormier, Y迪谢纳A1, C A1 Israel-Assayag, E A1 Bedard G A1 Laviolette, M A1多,年199188bet官网地址7 UL //www.qdcxjkg.com/content/10/7/1516.abstract AB接触猪监禁建筑对呼吸健康有负面影响。短时间暴露于这种环境会导致急性呼吸道炎症反应。本研究的目的是确认和进一步确定在猪舍中工作的急性效应，并确定这些效应是否可重复。七以前nonexposed正常受试者进行了评估,包括每小时测量在一秒用力呼气量(FEV1),醋甲胆碱挑战(挑衅浓度生产FEV1下降20% (PC20)),支气管肺泡灌洗(BAL),鼻灌洗(NL)和血液分析,之前(控制),之后每两个5 h暴露一个猪建筑环境。暴露时间间隔为8天。每天在隔离室内测量总粉尘、内毒素和氨(NH3)的水平。两组暴露均导致FEV1显著降低(FEV1的平均+/-SEM变化:对照= 7+/-2%;暴露1 = 15+/-3%;暴露2 = 23±3%，PC20下降(中位值(第25 -75百分位):223(23-256)，20(15-198)和20 (11-71);其中，BAL细胞(129+/-20、451+/-43和511+/-103x10(3)细胞分别为x mL(-1)和NL细胞(6+/-4、126+/-58和103+/-26x10(3)细胞分别为x mL(-1)，多为中性粒细胞。 Levels of interleukin-8 (IL-8), but not interleukin-1 (IL-1) or tumour necrosis factors (TNF-alpha), increased both in BAL and nasal fluids with exposure. In normal naive subjects, repeated exposure to the environment of a swine building induced a marked and reproducible reduction in forced expiratory volume in one second, increase in airway responsiveness, and increased neutrophilic inflammatory response. These results could not be accounted for by any of the environmental factors measured.