RT轴颈文章SR电子T1齿形素（WAL 801CL）通过前期的5-HT1样受体JF欧洲呼吸期刊Jo EUR RESPIR J FD欧洲呼吸学会SP 1433 OP 1438 VO 9，在体外调节豚鼠气道中的非胆管能收缩。188bet官网地址7 A1 Dupont，LJ A1 Meade，CJ A1 Demedts，MG A1 Verleden，GM YR 1996 UL //www.qdcxjkg.com/content/9/7/1433.Abstract Ab电场刺激（EFS）的几内亚猪在体外，呼吸唤起兴奋性的非肾上腺素能（Encance）收缩，通过从感觉神经末梢释放肠肽介导的介导。齿素（WAL 801CL）是一种在某些其他受体中具有结合亲和力的抗组胺药药物，包括α-肾上腺素能受体和各种血清素（5-HT）受体亚型。它用于哮喘治疗;但是，它的行动机制仍有待完全定义。我们研究了卓越素是否可以在体外调节豚鼠气道中的ENANC收缩，并试图阐明其受体机制。卓越素（0.1-100 microM）产生浓度依赖性抑制非胆管能收缩，最大抑制为100微米，最大抑制91 +/- 7％。用组合的5-HT1 / 5-HT2拮抗剂，甲虫合剂（1 microm）或甲硫酸（0.1 microm）进行预处理，显着减弱了梭子对非胆管能收缩的抑制作用。用对象异（1 microm），5-HT3拮抗剂，ketanserin（10 microm），5-HT2拮抗剂，硫代酰胺（10 microm），组胺H3拮抗剂或芬兰胺（10 microM），α-肾上腺素能拮抗剂， however, had no effect. Chlorpheniramine (10 microM), another histamine H1 receptor antagonist without significant 5-HT receptor binding affinity, did not produce any inhibition of the eNANC contraction. Epinastine (100 microM) did not displace the dose-response curve to exogenously applied substance P (0.01-10 microM). These results suggest that epinastine, although identified as a 5-HT antagonist, acts as a 5-HT1 agonist and that it inhibits the noncholinergic contraction in guinea-pig airways through stimulation of a prejunctional 5-HT1-like receptor, located to sensory nerves.