TY - T1的评估一个新的断续器设备测量支气管反应和响应以3岁儿童支气管扩张剂JF -欧洲呼吸杂志》乔和J SP - 1374 LP - 1380欧元六世- 9 - 7盟Phagoo某人AU -威尔逊,纳米非盟-西尔弗曼,M Y1 - 1996/07/01 UR - //www.qdcxjkg.com/content/9/7/1374.abstract N2 -断续器技术测量气道阻力非侵入性和方便,因此非常适合用于评估学龄前儿童气道口径的诱导变化。本研究的目的是评估一种市售的中断装置(基于Microlab 4000)，该装置在安静呼吸期间短暂中断呼气后，根据压力和流量计算中断器电阻(Rint)。评估了Rint的重复性，并将其对乙酰胆碱刺激和支气管扩张剂沙丁胺醇的反应与间接技术进行了比较，使用敏感性指数(SI，即刺激后的变化，以基线标准差的倍数表示)对12名喘息儿童(3岁+/- 2个月)的经皮氧张力(Ptc,O2)的下降进行了比较。Rint的平均(SD)基线值为0.91 (0.20)kpa . l . 1.s。Rint的短期重复性和基线变异性令人满意(组内相关系数= 0.6;平均受试者内变异系数= 13%)。虽然12名受试者中有10名在最大支气管收缩(即SI >2)总体而言，Rint的敏感性比Ptc,O2低5倍(几何平均SI: Rint 3 vs Ptc,O2 16;p & lt; 0.0001). Reversal of obstruction with administration of a bronchodilator was clearly demonstrated in almost all subjects: Rint after challenge (mean +/- SD) 1.25 (0.22) kPa.L-1.s; after salbutamol 0.78 (0.19) kPa.L-1.s; p < 0.001. In conclusion, the convenient interrupter resistance method appears more promising for detecting bronchodilator responses than induced bronchoconstriction in wheezy preschool children; however, measurement of transcutaneous oxygen tension provides a reliable indirect means of detecting induced airway obstruction in this age-group. ER -