TY - T1的评估一个新的断续器设备测量支气管反应和响应以3岁儿童支气管扩张剂JF -欧洲呼吸杂志》乔和J SP - 1374 LP - 1380欧元六世- 9 - 7盟Phagoo某人AU -威尔逊,纳米非盟-西尔弗曼,M Y1 - 1996/07/01 UR - //www.qdcxjkg.com/content/9/7/1374.abstract N2 -测量气道阻力的中断技术是无创的和方便的，因此非常适合评估学龄前儿童气道口径的诱导变化。这项研究的目的是评估一种商用的中断器(基于Microlab 4000)，它可以根据安静呼吸期间短暂中断呼气后的压力和流量计算中断器电阻(Rint)。我们评估了Rint的重复性，并将其对甲胆碱刺激和支气管扩张剂沙丁胺醇的反应与间接技术进行了比较，使用敏感性指数(SI, O2, Ptc)来衡量经皮氧张力(Ptc,O2)的下降。例如，12名喘息儿童(3岁+/- 2个月)在挑战后的变化以基线标准差的倍数表示。Rint的平均基线值为0.91 (0.20)kPa.L-1.s。Rint的短期重复性和基线变异性令人满意(类内相关系数= 0.6;平均学科内变异系数= 13%)。虽然12名受试者中有10名在最大支气管收缩时使用Rint获得显著反应(即SI >2)，总的来说，Rint比Ptc,O2的敏感性低5倍(几何平均SI: Rint 3 vs Ptc,O2 16; p < 0.0001). Reversal of obstruction with administration of a bronchodilator was clearly demonstrated in almost all subjects: Rint after challenge (mean +/- SD) 1.25 (0.22) kPa.L-1.s; after salbutamol 0.78 (0.19) kPa.L-1.s; p < 0.001. In conclusion, the convenient interrupter resistance method appears more promising for detecting bronchodilator responses than induced bronchoconstriction in wheezy preschool children; however, measurement of transcutaneous oxygen tension provides a reliable indirect means of detecting induced airway obstruction in this age-group. ER -