TY - T1的评估一个新的断续器设备测量支气管反应和响应以3岁儿童支气管扩张剂JF -欧洲呼吸杂志》乔和J SP - 1374 LP - 1380欧元六世- 9 - 7盟Phagoo某人AU -威尔逊,纳米非盟-西尔弗曼,M Y1 - 1996/07/01 UR - //www.qdcxjkg.com/content/9/7/1374.abstract N2 -测量气道阻力的阻断技术是非侵入性和方便的，因此非常适合于评估学龄前儿童诱导的气道口径变化。本研究的目的是评估一种商业上可用的中断器设备(基于Microlab 4000)，该设备通过压力和流量计算在安静呼吸期间短暂的呼气中断后的中断电阻(Rint)。评估Rint的重复性，并将其对methacholine刺激和支气管扩张剂沙丁胺醇的反应与间接技术、经皮氧张力(Ptc,O2)的下降进行比较，使用灵敏度指数(SI，即，挑战后的变化以基线标准差的倍数表示)，12例喘息患儿(3岁+/- 2个月)。Rint的平均(SD)基线值为0.91 (0.20)kPa.L-1.s。Rint的短期重复性和基线变异性令人满意(类内相关系数= 0.6;平均受试者内变异系数= 13%)。尽管12名受试者中有10人在最大支气管收缩时使用Rint获得显著反应(即SI >2)总体而言，Rint的灵敏度是Ptc、O2的5倍(几何平均SI: Rint 3 vs Ptc、O2 16; p < 0.0001). Reversal of obstruction with administration of a bronchodilator was clearly demonstrated in almost all subjects: Rint after challenge (mean +/- SD) 1.25 (0.22) kPa.L-1.s; after salbutamol 0.78 (0.19) kPa.L-1.s; p < 0.001. In conclusion, the convenient interrupter resistance method appears more promising for detecting bronchodilator responses than induced bronchoconstriction in wheezy preschool children; however, measurement of transcutaneous oxygen tension provides a reliable indirect means of detecting induced airway obstruction in this age-group. ER -