@文章{Shimura1395，作者= {S Shimura和Y Andoh和M Haraguchi和K Shirato}，标题={支气管哮喘患者气道内气道杯状细胞和腔内粘液的连续性}，体积={9}，数量={7}，页数={1395—1401}，年份={1996}，出版商={欧洲呼吸学会}，摘要={本研究的目的是阐明支气管哮喘患者尸检肺中观察到的广泛粘液堵塞的形成机制。188bet官网地址我们对8例支气管哮喘(BA组)患者的尸检肺气道进行了形态计量学分析，并与6例慢性支气管炎(CB组)和4例对照组(control)进行了比较。石蜡切片测量以下参数:支气管腺体占支气管壁的体积比例(Gland\%);杯状细胞颗粒占总上皮层的比例(杯状\%);腔内黏液以黏液占用率(MOR)表示;连续有杯状细胞的腔内黏液占腔内黏液总量的体积比(Vc/Vtol \%);连续有杯状细胞的腔内黏液接触表面与腔内总表面的比值(Sc/Stot \%)。BA组和CB组气道壁上的Gland\%、Goblet \%、MOR或炎性细胞数量均高于对照组。BA组与CB组的Gland\%、Goblet \%、MOR、炎性细胞数均无显著性差异，但其中嗜酸性粒细胞数为23 +/- 3,22 +/- 3和6 +/- 2 %;22 +/- 9,5 +/- 4和2 +/- 2\%酒杯\%; 10 +/- 3, 18 +/- 3 and 0.3 +/- 0.5\% in MOR; 199 +/- 68, 10 +/- 3 and 2 +/- 2 cells. mm-2 in eosinophil number of the peripheral airways from Groups BA, CB and Control, respectively. In contrast, marked and significant increases were observed both in Vc/Vtot\% and Sc/Stot\% in Group BA compared to Groups CB and Control both in central and peripheral airways: i.e. Vc/Vtot\% in the peripheral airways was 53 +/- 5, 4 +/- 3 and 0.8 +/- 0.8\% from Groups BA, CB and Control, respectively (BA vs CB or BA vs Control, p \< 0.01 each). These findings suggest that the continuity of goblet cells and intraluminal mucus or lack of full release of mucus, from goblet cells, is peculiar to asthmatic airways, and may contribute to the formation of mucous-plugs.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/9/7/1395}, eprint = {//www.qdcxjkg.com/content/9/7/1395.full.pdf}, journal = {European Respiratory Journal} }