文章AU - Hofstra, WB AU - Sterk, PJ AU - Neijens, HJ AU - Kouwenberg, JM AU - Mulder, PG AU - Duiverman, EJ TI -哮喘儿童运动迟发反应的发生:使用时间匹配基线和组胺控制的多元回归方法DP - 1996年7月1日TA -欧洲呼吸杂志PG - 1348—1355 VI - 9 IP - 7 4099 - //www.qdcxjkg.com/content/9/7/1348.short 4100 - //www.qdcxjkg.com/content/9/7/1348.full SO - Eur Respir J1996年7月1日;9 AB -目前，关于哮喘患者运动挑战是否存在晚期哮喘反应(LAR)仍存在争议。因此，我们调查了在门诊就诊的哮喘儿童运动后发生LAR的情况，使用时间匹配的基线和组胺控制天数，并根据最近发表的建议进行统计分析。在筛查运动日之后，17名儿童(7-14岁)在随后的三个研究日随机进行:第二次标准化运动挑战;或者在运动后与支气管收缩相匹配的同时进行组胺挑战;或测量基线肺功能没有任何挑战。在8小时内重复测量1秒用力呼气量(FEV1)。以FEV1为依赖变量，以运动后2-8小时内测试日(运动或对照)和时钟时间为自变量，对每位患者进行多元回归分析。显著相互作用(p <试验日和时钟时间之间的0.05)被认为是LAR的指示。 Fifteen children completed the study. All children showed an early asthmatic reaction to exercise (range 14-62% fall in FEV1). In two children, a significant interaction (p < 0.05) was found between test day and clock time. However, the difference in FEV1 between exercise and control days for each clock time did not exceed the 99.6% confidence limits of normal diurnal variation in any of the children. We conclude that, in children with mild-to-moderate asthma, a LAR to exercise does not occur. This suggests that exercise is only a symptomatic trigger of asthma. Whether exercise is capable of inducing inflammation needs to be further investigated.