TY - JOUR T1 -哮喘儿童运动迟发反应的发生:多元回归方法使用time-matched基线和组胺控制天JF -欧洲呼吸杂志》乔和J SP - 1348 LP - 1355欧元六世- 9 - 7非盟-霍夫斯特拉,世行非盟-斯德克已PJ盟——Neijens HJ盟——Kouwenberg JM盟——穆德,PG盟——Duiverman EJ Y1 - 1996/07/01 UR - //www.qdcxjkg.com/content/9/7/1348.abstract N2 -目前,仍有争论关于哮喘反应后期的存在(政治)在哮喘锻炼挑战。因此，我们调查了在门诊就诊的哮喘儿童运动后发生LAR的情况，使用时间匹配的基线和组胺控制天数，并根据最近发表的建议进行统计分析。在筛查运动日之后，17名儿童(7-14岁)在随后的三个研究日随机进行:第二次标准化运动挑战;或者在运动后与支气管收缩相匹配的同时进行组胺挑战;或测量基线肺功能没有任何挑战。在8小时内重复测量1秒用力呼气量(FEV1)。以FEV1为依赖变量，以运动后2-8小时内测试日(运动或对照)和时钟时间为自变量，对每位患者进行多元回归分析。显著相互作用(p <试验日和时钟时间之间的0.05)被认为是LAR的指示。15名儿童完成了这项研究。 All children showed an early asthmatic reaction to exercise (range 14-62% fall in FEV1). In two children, a significant interaction (p < 0.05) was found between test day and clock time. However, the difference in FEV1 between exercise and control days for each clock time did not exceed the 99.6% confidence limits of normal diurnal variation in any of the children. We conclude that, in children with mild-to-moderate asthma, a LAR to exercise does not occur. This suggests that exercise is only a symptomatic trigger of asthma. Whether exercise is capable of inducing inflammation needs to be further investigated. ER -