TY -的T1 breathhold在呼气流量峰值的影响在正常和哮喘儿童JF -欧洲呼吸杂志》乔和J SP - 1363 LP - 1367欧元六世- 9 - 7盟松本,我非盟-沃克,年代盟——狡猾,PD Y1 - 1996/07/01 UR - //www.qdcxjkg.com/content/9/7/1363.abstract N2 -我们曾表现出最大呼气流量(PEF)减少10%的健康成人后breathhold在肺活量(TLC)。这种下降归因于气道壁粘弹性的耗散，增加了气道壁顺应性(Caw)。为了在儿童中研究这一现象，并确定屏气对哮喘儿童的影响是否比正常儿童更大，15名哮喘儿童和14名正常儿童(10-15岁)在TLC中进行最大呼气后(MFE)，有和没有5 s屏气。整个研究在吸入沙丁胺醇(800微克)后重复进行，以放松气道平滑肌(并增加Caw)。TLC呼吸使两组哮喘患者的PEF均显著下降(组平均下降5.8%;p & lt;0.01)和正常儿童(组平均下降10.3%;p & lt;0.05)。沙丁胺醇在这个秋天减少了，在正常儿童中变得不显著。 Similar patterns were also seen in forced expiratory volume in one second (FEV1) and in maximal expiratory flow at 50% vital capacity (V'50). These data are consistent with the proposal that breathhold at total lung capacity dissipated viscoelastic energy (increasing airway compliance) and decreased maximal expiratory flows both in normal and asthmatic children. They also demonstrate the need to standardize the forced vital capacity manoeuvre to decrease the variability in the flows recorded during the subsequent forced expiration. ER -