RT期刊文章SR Electronic T1共发病有助于预测慢性阻塞性肺疾病患者的死亡率JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 2794 OP 2800 DO 10.1183/09031936.97.10122794 VO 10 IS 12 A1 Antonelli Incalzi, R A1 Fuso, L A1 De Rosa, M A1 188bet官网地址Forastiere, F A1 Rapiti, E A1 Nardecchia, B A1 Pistelli，R YR 1997 UL //www.qdcxjkg.com/content/10/12/2794.abstract AB本研究的目的是评估重度慢性阻塞性肺疾病(COPD)的共发病的预后作用。270例COPD患者的队列，平均(+/-SD)年龄67+/-9岁，连续从一所大学医院急性加重后出院。平均(+/-SD) 1秒用力呼气量(FEV1)为预测值的34+/-16%，FEV1/用力肺活量(FVC)为40.5+/-13.8%。最常见的共病疾病是:高血压(28%)、糖尿病(14%)和缺血性心脏病(10%)。从临床记录中收集出院时的临床、心电图(ECG)和呼吸功能数据。Charlson指数用于量化共病。通过电话进行了后续调查。多变量生存分析用于确定死亡的独立预测因素。队列的中位生存期为3.1年。 Death was predicted by the following variables: age (hazard rate (HR) 1.04; 95% confidence intervals (95% CI) 1.02-1.05), ECG signs of right ventricular hypertrophy (HR 1.76; 95% CI 1.30-2.38), chronic renal failure (HR 1.79; 95% CI 1.05-3.02), ECG signs of myocardial infarction or ischaemia (HR 1.42; 95% CI 1.02-1.96), FEV1 < 590 mL (HR 1.49; 95% CI 0.97-2.27). A score based upon these variables predicted mortality at 5 yrs with a sensitivity of 63% and a specificity of 77%. Selected co-morbid diseases and electrocardiogram signs of right ventricular hypertrophy play a major prognostic role in advanced chronic obstructive pulmonary disease. The clinical assessment of patients with chronic obstructive pulmonary disease should include these important and easily measurable variables.