TY - JOUR T1 -为纺织印花工人组织肺炎:JF - European Respiratory Journal JO - Eur Respir J SP - 265 LP - 271 VL - 11 IS - 2 AU - Romero, S AU - Hernandez, L AU - Gil, J AU - Aranda, I AU - Martin, C AU - Sanchez-Paya，J Y1 - 1998/02/01 UR - //www.qdcxjkg.com/content/11/2/265.abstract N2 - 1992年4月，在西班牙巴伦西亚自治社区Alcoi地区的航空纺织工人中暴发了严重的呼吸道疾病。一项流行病学研究将此次疫情与一种重新配方的雾化产品Acramin-FWN的使用联系起来。我们分析了最初14例由这种新认识的职业毒物继发的组织性肺炎(OP)患者的临床、实验室和病理数据。患者平均年龄30岁。最常见的临床表现为咳嗽(86%)、鼻出血(71%)、呼吸困难(64%)、压迫性胸痛(57%)和噼啪(50%)。64%有明显的限制性功能模式。影像学表现主要为65%的斑片状浸润，35%为小结节。在14例患者中，有11例接受皮质类固醇治疗并没有防止最初的进展，5例患者发展为不可逆的呼吸衰竭。 At necropsy, besides features of OP, interstitial fibrosis and diffuse alveolar damage were evident. A low total lung capacity, the presence of crackles at admission, and increases in the alveolar-arterial oxygen difference were predictive of death. The organizing pneumonia caused by the inhalation of Acramin-FWN is characterized by a tendency to evolve into progressive interstitial fibrosis despite the use of corticosteroids. The illness is restricted to the respiratory system and once respiratory failure has developed the prognosis is poor. ER -