TY - T1的非侵入性的突变阈值和强度的咳嗽在人类JF -欧洲呼吸杂志》乔和J SP - 983 LP - 989欧元六世- 10 - 5盟丰塔纳,GA盟——佛罗伦萨,T非盟- Lavorini F AU - Boddi, V盟——Panuccio在呼吸医学中，咳嗽阈值和强度的评估是很重要的。我们开发了一种客观、无创的方法来评估超声雾化蒸汽水(UNDW)吸入后的咳嗽阈值和呼气肌努力强度。在36名志愿者中，有30人(83%)在吸入UNDW后咳嗽。咳嗽阈值被认为是在每30分钟进行两次挑战时引起咳嗽的最低雾化器输出量(mL x min(-1))。在阈值水平，评估腹肌综合肌电图(IEMG)活动的峰值和斜率的重复性。分别在间隔3小时和6-9个月后，对15名受试者的咳嗽阈的短期和长期重复性进行评估。我们还研究了喷雾器输出与iemg相关变量之间的剂量-反应关系，以及iemg与自愿咳嗽时呼气流量之间的关系。中位(1、3分位)咳嗽阈值分别为0.89(0.40、1.54)mL x min(-1)。在阈值水平上，IEMG活性的峰值和斜率具有较高的重现性。 Cough threshold displayed a high degree of short- and long-term repeatability. Peak and slope of IEMG activity displayed a clear trend to increase (p<0.01) following inhalation of progressively higher UNDW outputs. Maximum flow during voluntary coughs of varying intensity correlated with the peak (p<0.05) and, more closely, with the slope (p<0.01) of abdominal IEMG activity. The assessment of cough threshold as well as the evaluation of the intensity of cough efforts by abdominal integrated electromyographic recordings may represent useful and reliable tools for cough research in humans. ER -