PT -期刊文章AU - Beckett, WS AU - Pace, PA AU - Sferlazza, SJ AU - Carey, VJ AU - Weiss，圣TI -年度变化醋甲胆碱反应nonasthmatic成年工作者DP - 1997年11月01 TA -欧洲呼吸杂志》第六PG - 2515 - 2521 - 10的IP - 11 4099 - //www.qdcxjkg.com/content/10/11/2515.short 4100 - //www.qdcxjkg.com/content/10/11/2515.full所以欧元和J1997 11月01;10 AB -气道反应性的改变是临床和流行病学常用的工具。气道反应性的变化可能优于其他测量肺功能的指标，因为它们是环境影响的更敏感的指标。然而，在解释变化之前，必须定义测试结果的正常变化。为了描述气道反应性的年度变异性，我们给予105名健康的、无哮喘的工作受试者4年的高剂量甲胆碱刺激，间隔1年。使用这种高剂量方案，大多数试验(83%)使一秒钟内用力呼气量(FEV1)至少下降20%，允许标准计算甲基胆碱刺激剂量导致FEV1 (PD20)下降20%。每年至少有30%的受试者接受一倍以上剂量的甲胆碱反应性变化。对气道反应性测量的变异成分进行估计，以便直接比较受试者内部和受试者之间的变异。受试者PD20的受试者内可变性明显大于FEV1的受试者内可变性。 Level of FEV1 and age were both significant determinants of methacholine responsiveness. Comparison of two methods of expressing methacholine responsiveness (PD20 using the full challenge up to 250 mg x mL(-1) methacholine, and the dose-response slope using data up to 32 mg x mL(-1) methacholine as the maximum dose) had similar annual variability in censored data and mixed-effects models. We then developed an approach to statistical analysis of "right-censored" methacholine challenge data using a maximum likelihood estimation under a censored Gaussian model. These studies of methacholine responsiveness provide normative data on annual test variability in healthy, nonasthmatic working adults, and show that a shorter low-dose challenge has comparable annual variability to a lengthier high-dose challenge.