RT期刊文章SR电子T1免疫发现血液和支气管肺泡血液中慢性支气管炎患者复发性传染性加剧JF欧洲呼吸期刊Jo EUR RESPIR J FD欧洲呼吸学会SP 46 OP 54 VO 11是1 A1 QVARFORDT，I A1 RIISE，GC188bet官网地址A1 Larsson，S A1 Almqvist，G A1 Rollof，J A1 Bengtsson，T A1 Andersson，BA YR 1998 UL //www.qdcxjkg.com/content/11/1/46.Abstract Ab支气管感染在吸烟者和吸烟者中很常见似乎与慢性支气管炎（CB）的存在有关。为什么只有一些吸烟者发展反复的支气管感染是不知道的。本研究的目的是筛选与患有CB患者和反复感染性加剧的疾病相关的免疫变化，与无症状吸烟者相比。十六名吸烟者，具有稳定的CB和复发性传染性加剧和18个无症状吸烟者，所有无论没有任何免疫调节治疗，都经过支气管镜检查和支气管肺泡灌洗（BAL）。吸烟历史和目前的吸烟状况是可比的。测定了血清免疫球蛋白（Ig）A，IgM，IgG和IgG亚类。分析了外周血单核细胞（PBMC）对各种刺激器的血液和BAL淋巴细胞表型和增殖反应。测定了PBMC培养物中细胞因子的未刺激和破伤风毒素刺激的产生。 Natural killer (NK-) cell activity was analysed. A significantly (p<0.05) lower level of IgG3 was found in the CB group, and a significantly (p<0.01) higher proliferative response of PBMCs was found in the CB group after stimulation with diphtheria toxoid. Detectable levels of interleukin (IL)-6, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma, but not of IL-2, IL-4 or transforming growth factor-beta2, were found in supernatants from cultured cells in both study groups. Stimulated TNF-alpha production was significantly (p<0.05) higher in the CB group. NK-cell activity did not differ significantly between the study groups. There were no major differences between the groups in lymphocyte subpopulations in blood or BAL. In conclusion, no major alterations in the analysed indices of cell-mediated and humoral immunity were found in patients with chronic bronchitis prone to recurrent infectious exacerbations when compared with asymptomatic smoking controls.