@article {Anderson2465作者={安德森、SD和春天,J和摩尔,B和罗德威尔,LT和斯伯丁,N和Gonda,我和陈,K和沃尔什和克拉克,AR}, title ={的干粉吸入氯化钠的影响哮喘的气道主题},体积={10}={11},页面= {2465 - 2473}= {1997},含4.5\%氯化钠(NaC188bet官网地址l)的湿气溶胶常被用于评估哮喘相关的支气管反应性。我们质疑干氯化钠是否可以作为一种替代。从含5、10、20或40 mg的胶囊中吸入干粉NaCl，累积剂量为635 mg。粉末通过吸入器或Halermatic输送。比较24例19 ~ 39岁哮喘患者对干、湿氯化钠的气道敏感性。所有受试者对两种准备都有反应，对刺激剂量的NaCl(使1秒内用力呼气量(FEV1)从基线下降20 % (PD[20,NaCl])的几何平均值(95 %置信区间)(干NaCl为103 mg(68-157)，而湿NaCl为172 mg (102-292)， p <0.03。对干氯化钠的响应是重复的，在重复挑战PD20为108 mg(75-153)。在两个试验日的每一天，FEV1的平均最大下降约为25%。在干氯化钠刺激后60分钟内和使用支气管扩张剂后5分钟内发生自发恢复。 There were no serious side-effects requiring medical attention, however some patients coughed on inhalation of the 40 mg dose and three gagged. Arterial oxygen saturation remained within normal limits. We conclude that a suitably prepared dry powder of sodium chloride could potentially replace wet sodium chloride to assess bronchial responsiveness in patients with asthma, but further studies are required to establish the long-term stability of the dry powder preparation.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/10/11/2465}, eprint = {//www.qdcxjkg.com/content/10/11/2465.full.pdf}, journal = {European Respiratory Journal} }