@Article {Lemiere241，作者= {Lemiere，C和Malo，JL和Boutet，M}，标题= {反应气道功能障碍综合征由于氯：顺序支气管活组织检查和功能评估}，体积= {10}，数字= {1}，页面= {241--244}，年= {1997}，出版商= {欧洲呼吸社会}，摘要= {非常少的信188bet官网地址息可用于由反应气道功能障碍综合征（RADS）引起的急性组织病理学支气管改变。我们有机会在氯（急性暴露后60小时，15天，2和5个月的氯（60小时，15天，2和5个月）中进行顺序支气管活组织检查，并评估肌肉素和支气管对甲素的反应性。一个36岁的水过滤植物（Nonsmoker）在1994年9月12日突然吸入高浓度的氯。他经历了立即鼻腔和喉咙燃烧，retronternal燃烧和喘息，并且这些症状在工作期间和之后持续存在。两天后，他抱怨retronternal燃烧，呼吸困难和喘息。鼓舞人力喘息于记录。他在一秒钟（FEV1）中的强制呼气量为66 \％预测，甲素的挑衅性浓度导致20℃的甲素均落在FEV1（PC20）中略微异常（2.5mg.ml -1）。第二天，患者接受了支气管活组织检查，这表明通过纤维核美卤蛋白渗出几乎完全替代上皮。受试者被规定的吸入类固醇。事故发生后十五天，PC20得到改善至6毫克-1。 Bronchial biopsies showed considerable epithelial desquamation with an inflammatory exudate and swelling of the subepithelial space. Five weeks after the accident, the PC20 was normal (57 mg.mL-1). Inhaled steroids were stopped. Two months after the accident, the PC20 deteriorated to 4 mg.mL-1. Biopsies then showed regeneration of the epithelium by basal cells and there was still a pronounced inflammatory infiltrate. Inhaled steroids were restarted. Three and five months later, the PC20 was normal (24 mg.mL-1). Bronchial biopsies showed a greatly improved epithelium and reduction of the inflammatory infiltrate. This case report shows that reactive airways dysfunction syndrome can cause acute, marked, though partially reversible, histological abnormalities. Inhaled steroids may modulate changes in bronchial responsiveness in this condition.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/10/1/241}, eprint = {//www.qdcxjkg.com/content/10/1/241.full.pdf}, journal = {European Respiratory Journal} }