RT期刊文章SR电子T1在肺纤维化中增加上皮通透性与疾病进展有关JF欧洲呼吸系统杂志的关系JO EUR呼吸j fd欧洲呼吸学会SP 184 OP 190 DO 10.1183/09031936.00010910 vo 38 IS 1 A1 GOH，N.S.L。188bet官网地址A1 Desai，S.R。A1 Anagnostopoulos，C。A1Hansell，D.M。A1 Hoyles，R.K。A1 Sato，H。A1 Denton，C.P。A1 Black，C.M。A1 Du Bois，R.M。A1 Wells，A.U。YR 2011 UL //www.qdcxjkg.com/content/38/1/184.44.abstract上的上皮损伤有助于特发性肺纤维化（IPF）的发病机理，但其在全身性硬化（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）（ILD）SSC）不确定。我们量化了吸入technetium-99m（99mtc）标签的二乙二烯三亚胺五乙酸（DTPA）肺清除率的预后意义，这两种疾病是上皮损伤程度的标志。 Baseline 99mTc-DTPA pulmonary clearance was evaluated retrospectively in patients with SSc-ILD (n = 168) and IPF (n = 97) against mortality and disease progression. In SSc-ILD, the rapidity of total clearance (hazard ratio (HR) 1.02, 95% CI 1.01–1.03; p = 0.001) and the presence of abnormally rapid clearance (HR 2.10; 95% CI 1.25–3.53; p = 0.005) predicted a shorter time to forced vital capcity (FVC) decline, independent of disease severity. These associations were robust in both mild and severe disease. By contrast, in IPF, delayed clearance of the slow component, an expected consequence of honeycomb change, was an independent predictor of a shorter time to FVC decline (HR 1.01, 95% CI 1.00–1.02; p<0.01). Epithelial injury should be incorporated in pathogenetic models in SSc-ILD. By contrast, outcome is not linked to the overall extent of epithelial injury in IPF, apart from abnormalities ascribable to honeycombing, suggesting that core pathogenetic events may be more spatially focal in that disease.