RT期刊文章SR电子T1与支气管洗涤，支气管洗涤，支气管肺泡灌洗和支气管活检的比较COPD JF欧洲呼吸杂志188bet官网地址Kaufmann, HF A1 van der Mark, TW A1 Koeter, GH A1 Postma, DS YR 2000 UL //www.qdcxjkg.com/content/15/1/109.abstract AB It is unclear how cellular and soluble inflammatory markers in诱导的痰与灌洗液中的标记和慢性阻塞性肺疾病（COPD）中的活检有关。对此进行了研究，并评估了COPD和健康对照的受试者之间的可能差异。研究了18名具有COPD和11个健康对照的非原子受试者。痰是通过吸入高渗盐水诱导的。使用前50毫升进行支气管洗涤（BW），然后将气道灌输，随后的150毫升用于支气管肺泡灌洗（BAL），并从亚段carinae中取下活检。嗜中性粒细胞是COPD中痰中的主要细胞类型（中位77.3％），但在BW（5.5％）和BAL液（1.7％）中不是。痰中的差异细胞计数与BW，BAL流体或活检中的计数无关，而嗜酸性粒细胞阳离子阳离子蛋白（ECP）水平与BW流体ECP水平相关（P = 0.66，P = 0.007）和Sputum Iltleukin-8（IL（IL）（IL）（IL）（IL）（IL）-8）用BAL流体IL-8浓度浓度（p = 0.52，p = 0.026）。患有COPD的受试者比健康对照组具有更高比例的痰中性粒细胞和嗜酸性粒细胞，ECP和IL-8浓度更高。 The higher percentages of eosinophils and concentrations of ECP were also seen in BW and BAL fluid. Finally, higher numbers of macrophages and eosinophils were found in biopsies. In conclusion, induced sputum is derived from a different compartment from BW and BAL fluid and biopsies. Induced sputum may be useful for studying the contribution of luminal neutrophils and eosinophils in chronic obstructive pulmonary disease.