@Article {Rutgers109，作者= {Rutgers，SR和Timens，W和Kaufmann，HF和Van der Mark，TW和Koeter，GH和邮政编码，Title = {诱导痰与支气管洗涤，支气管肺泡灌洗和支气管的比较COPD中的活检}，体积= {15}，Number = {1}，页面= {109--115}，年= {2000}，发布者= {欧洲呼吸协会}，摘要= {目不的是如何蜂窝和可溶性188bet官网地址诱导痰中的炎症标志物涉及灌洗液中的标志物和慢性阻塞性肺病（COPD）中的活组织检查。研究了这一点以及评估了COPD和健康对照的受试者可能的差异。研究了具有COPD和11种健康对照的18个非储物对象。通过吸入高渗盐水诱导痰。使用前50ml用于支气管洗涤（BW）和随后的支气管肺泡灌洗（BAL）和活组织检查，从亚宫颈植物灌洗（BAL），气道锻炼。中性粒细胞是COPD中的痰中的主要细胞类型（中位数77.3 \％），但不含BW（5.5 \％）和BAL流体（1.7 \％）。痰中的差异细胞计数与BW或BAL流体或活组织检查中的计数无关，而痰液嗜酸性粒细胞阳离子蛋白（ECP）水平与BW流体ECP水平相关（P = 0.66，P = 0.007）和痰白细胞介素-8（IL-8）BAL流体IL-8浓度的浓度（p = 0.52，p = 0.026）。具有COPD的受试者具有更高的痰中性粒细胞和嗜酸性粒细胞和嗜酸性粒细胞和更高浓度的ECP和IL-8而不是健康对照。 The higher percentages of eosinophils and concentrations of ECP were also seen in BW and BAL fluid. Finally, higher numbers of macrophages and eosinophils were found in biopsies. In conclusion, induced sputum is derived from a different compartment from BW and BAL fluid and biopsies. Induced sputum may be useful for studying the contribution of luminal neutrophils and eosinophils in chronic obstructive pulmonary disease.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/15/1/109}, eprint = {//www.qdcxjkg.com/content/15/1/109.full.pdf}, journal = {European Respiratory Journal} }