TY - T1的血清1型和III procollag类型en peptide levels in sarcoidosis JF - European Respiratory Journal JO - Eur Respir J SP - 1648 LP - 1651 VL - 9 IS - 8 AU - Bacchella, L AU - Tinelli, C AU - Gile, LS AU - Peona, V AU - Aprile, C AU - Gorrini, M AU - Pasturenzi, L AU - Cetta, G AU - Luisetti, M Y1 - 1996/08/01 UR - //www.qdcxjkg.com/content/9/8/1648.abstract N2 - Type I and type III are the most abundant collagens in the lung. The aim of our study was to compare type I and III procollagen peptides in sera of sarcoid patients. Sixty eight patients with sarcoidosis were studied (19 with newly recognized disease, 7 with relapsing disease, 15 with chronic disease, and 27 in stable remission). Thirty healthy volunteers served as controls. The levels of procollagen I and III peptides were determined by radioimmunoassay. Angiotensin-converting enzyme (ACE) level was evaluated by means of a colorimetric assay. In patients with newly recognized sarcoidosis, both serum procollagen I and III peptide levels were increased with respect to controls (p=0.0014 and p<0.00001, respectively). There was a poor correlation between levels of procollagen I and III (r=0.26), whereas there was a closer correlation between procollagen III and ACE (r=0.69). Procollagen I peptide level did not identify patients in roentgenological stage III. In conclusion, in patients with newly recognized sarcoidosis there is a significant increase in the serum level of procollagen I peptide. However, procollagen I peptide is not a marker of sarcoid patients with fibrosis, ie. stage III disease. Its clinical usefulness seems to be weaker than that of procollagen III peptide. ER -