@article {tamaoki1632，作者= {tamaoki，j和chiyotani，a和tagaya，e和takemura，e and takemura，h和konno，k}，title = {兔气管旋转transepitheal transepitheal transepitheal transepitheal transepithelial transepithelial in vivo}，体积= {9}，9}，9}，9}，9}，9}，9}，9}，9}，9}，9}，9}，9}，9}，connumber = {8}，页面= {1632---1636}，年= {1996}，出版商= {欧洲呼吸社会}，摘要= {本研究的188bet官网地址目的是研究自主神经系统在气道上皮离子在体内的调节。通过插入在Cari​​na上方的套管进行麻醉和机械通知的兔子。暴露了上部气管粘膜，并通过在开路条件下通过高阻力电压表连续测量粘膜表面和粘膜下空间之间的电势差（PD）。用阿托品灌注的粘膜从-20.1 +/- 2.0迅速下降到-15.2 +/- 0.9 mV（P \ <0.01），而苯甲酚，普萘洛尔或tachykyinin拮抗剂FK224则没有作用。切割两种宫颈迷走神经均与阿托品相同的程度降低了PD。外源施用的乙酰胆碱以剂量依赖性方式增加了PD。溴化溴化物的局部应用以剂量依赖性方式降低了基线值PD。PD的最大降低为43 +/- 0.3 mV（p \ <0.01），产生半马日可能性效应所需的剂量为34 microg。 Perfusion with either amiloride, a Na channel blocker, and diphenylamine-2-carboxylate, a Cl channel blocker, decreased the baseline PD, and the subsequent application of ipratropium bromide further decreased the PD in each case. We conclude that a cholinergic neural component may play a role in the generation of tracheal potential difference in vivo, probably involving stimulation by endogenously released acetylcholine of both Cl secretion and Na absorption across the airway epithelium.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/9/8/1632}, eprint = {//www.qdcxjkg.com/content/9/8/1632.full.pdf}, journal = {European Respiratory Journal} }