TY - JOUR T1 -因职业性药物引起的发热和白细胞增多伴随哮喘反应:频率和相关因素JF -欧洲呼吸杂志》乔和J SP - 517 LP - 523欧元六世- 9 - 3盟Lemiere C盟——Gautrin D AU -特鲁多,C盟——Ghezzo H AU -德斯贾丁斯,非盟——卡地亚,非盟的目的,发热有时与职业性药剂吸入后的哮喘反应有关。我们的目的是评估通过特定吸入刺激确诊的职业性哮喘受试者中发热的流行率，并检查因特定吸入刺激而发热的受试者的特征和临床相关性。我们对317名对职业性药物特异性吸入刺激阳性的受试者进行了回顾性分析，并将特异性吸入刺激后出现发热的受试者与随机抽样的未出现发热的受试者进行了比较。15名受试者(5%)出现与阳性特异性吸入刺激相关的发热。他们与随机抽取的60名没有发烧的受试者进行了比较。发热组:1)特异性吸入性攻毒后，血中性粒细胞绝对数量增加较多，血淋巴细胞和强迫肺活量减少较多;2)包括较少的特应性;3)更频繁地接触低分子化合物而不是高分子化合物; and 4) always experienced a late reaction and had more atypical reactions. We conclude that after positive specific inhalation challenge; fever occurs infrequently, and is associated with an increase in blood neutrophils and a decrease in blood lymphocytes and forced vital capacity. Such reactions seem more likely to occur in nonatopic subjects exposed to low molecular weight agents. ER -