ty -jour t1-直径对支气管段和环的力产生和响应性的影响JF-欧洲呼吸杂志Y1-1996/03/01 UR- http://www.qdcxjkg.com/content/9/3/3/500.abstract n2-在这项研究中,使用异载体支气管段和支气管环来研究气道直径对气道的影响平滑肌力的产生和乙酰胆碱反应能力。内径范围为1.0-6.0毫米的片段,从八头猪的主要支气管中获得。对乙酰胆碱浓度升高的响应通过碎片内压(CMH2O)和张力(G.CM-1)在环中定量。为每个片段和环计算了产生一半最大效应(即PD2)(即PD2)一半(EC50)(即PD2)的负log。环张力用于计算每个环的理论管腔压力,并将其与PD2一起与从相同直径段获得的值进行比较。中等大小的段产生的量与大或小段明显更大。小段对乙酰胆碱的敏感性比大段高160倍。与片段相反,支气管环没有大小对乙酰胆碱敏感性的影响。 Theoretical ring lumen pressures matched those measured for large and intermediate segments, but not for small segments. The different behaviour of bronchial segments and rings obtained from the same sized airway suggests that the three-dimensional architecture of the airway is an important factor in determining behaviour, particularly in small airways. ER -