％0期刊文章％a gallico，l％a oggioni，n％a dalla rosa，c％a ceserani，r％a tognella，moguisteine的效果，一种对外周的非核酸抗毒剂的影响Vivo％D 1996％j欧洲呼吸道期限％p 478-485％V 9％n 3％x咳嗽是与刺激或炎症相关的呼吸道疾病的常见症状咳嗽反射。我们的目的是评估Moguisteine（一种新型，周围，非纳拉抗震荡剂）对具有多种刺激的几内亚猪炎症的炎症的影响。这些刺激包括暴露于烟草烟雾10分钟，以引起气道高反应性，支气管肺泡灌洗中的嗜酸性粒细胞募集（BAL），气道上皮损伤和血浆渗出；渐变血小板激活因子（PAF）输注（一h 600 ng.kg-1），以诱导气道高反应性；1％OA敏化动物的2％椭圆蛋白（OA）气溶胶挑战，以诱导后期（17和72 h）气道白细胞积累。我们还评估了辣椒素诱导的血浆泄漏，对乙酰胆碱（ACH），组胺（H）和PAF诱导的支气管收缩的血浆渗漏的活性，以及​​白细胞中介导的过敏性支气管痉挛在OA含量的几内亚 - 几内亚杆菌中。Moguisteine（P.O.和I.M.）和地塞米松（P.O.和I.M.）剂量依赖性地降低了烟草诱导的支气管性过度反应性。Moguisteine和地塞米松在BAL中废除了嗜酸性粒细胞的募集，防止了上皮的裂缝，并显着降低了气道微血管泄漏。 Both agents were also highly effective in reducing bronchial hyperreactivity elicited by PAF infusion. In addition, moguisteine was active in inhibiting airway neutrophil and eosinophil accumulation in BAL observed 17 and 72 h after OA challenge in sensitized guinea-pigs. In contrast to dexamethasone, moguisteine did not prevent capsaicin-induced plasma leakage. It was also ineffective against bronchoconstriction as induced by ACh, H, and PAF and failed to inhibit leukotriene-dependent bronchospasm. Our data suggest that moguisteine represents an antitussive compound endowed with interesting airway anti-inflammatory properties in guinea-pigs in vivo. Its mechanism of action remains to be elucidated. %U //www.qdcxjkg.com/content/erj/9/3/478.full.pdf