@Article {Sester100，作者= {Sester，M。和Sotgiu，G。和Lange，C。和Giehl，C。和Girardi，E。和Migliori，G.B。以及A.和Dheda，K。和Diel，R。以及Dominguez，J。和Lipman，M。和Nemeth，J。和Ravn，P。以及Winkler，S。和Huitric，E。和Sandgren，A。和Manissero，D。}，title = {干扰素 - γ释放分析测定，用于诊断活性结核病：系统评价和荟萃分析}，音量= {37}，number = {1}，页面= {100---111}，年= {2011}，doi = {10.1183/09031936.00114810}，Publisher = {欧洲呼吸社会}188bet官网地址，摘要= {Interferon-γ释放分析（IGRAS）现在已被建立，以用于对许多国家的延迟感染，许多国家的延发感染。。然而，IGRA在诊断活性结核病（TB）中的作用尚不清楚。遵循有关系统评价和荟萃分析（PRISMA）的首选报告项目（PRISMA）以及诊断准确性研究（QUADAS）指南的质量评估，我们搜索了PubMed，Embase和Cochrane数据库，以识别2001年1月发表的研究{\ textendendash} 2009年11月，评估了该研究，该研究评估了该研究的评估，该研究评估了该研究。直接在血液或外静脉样本上直接在血液或外静脉样本上使用Quantiferon-tb {\ textregistered}金管内（qft-g-it）和t-spot.tb {\ textregistered}的证据。文献搜索产生了844项研究，27项符合纳入标准。在血液和血液外液中，活性TB诊断的合并灵敏度为80 \％（95 \％CI 75 {\ TextEndEndash} 84 \％）和48 \％（95 \％CI 39 {\％CI 39 {\％）对于qft-g-it和81 \％（95 \％ci 78 {\ textendash} 84 \％）和88 \％（已确认和未经证实的案例）（95 \％ci 82 {\ textendash} 92 92 \％）对于t-spot.tb {\ textregistered}。 In blood and extrasanguinous fluids, the pooled specificity was 79\% (95\% CI 75{\textendash}82\%) and 82\% (95\% CI 70{\textendash}91\%) for QFT-G-IT, and 59\% (95\% CI 56{\textendash}62\%) and 82\% (95\% CI 78{\textendash}86\%) for T-SPOT.TB{\textregistered}, respectively. Although the diagnostic sensitivities of both IGRAs were higher than that of tuberculin skin tests, it was still not high enough to use as a rule out test for TB. Positive evidence for the use of IGRAs in compartments other than blood will require more independent and carefully designed prospective studies.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/37/1/100}, eprint = {//www.qdcxjkg.com/content/37/1/100.full.pdf}, journal = {European Respiratory Journal} }