TY - JOUR T1 - Anti-Borrelia burgdorferi immunoglobulin seroprevalence in pulmonary sarcoidosis: a negative report JF - European Respiratory Journal JO - Eur Respir J SP - 1356 LP - 1358 VL - 10 IS - 6 AU - Martens, H AU - Zollner, BAu -Zissel，G au -Burdon，D au -Schlaak，M au -Muller -Quernheim，J Y1-1997/06/01 Ur -http：//www.qdcxjkg.com/content/content/10/6/6/6/1356.abstractN2-结节病的病因仍然未知。无法鉴定出一种传染性的微生物作为这种疾病的因果剂，但是在中国研究中检测到了针对伯氏伯氏伯氏伯氏伯氏菌的抗体的高滴度。但是，这些发现不能由其他研究人员复制。因此，这项研究的目的是评估这些螺旋体在血清学检查中的结节病发病机理中的可能作用。检查了六十种患有结节病的患者的血清患有抗B。通过酶联免疫吸附测定法（ELISA），伯格多特里免疫球蛋白。这些抗体的ELISA显示出高灵敏度，但特异性低。因此，使用特定的免疫印迹来确认阳性结果。 Initially, 8% of the patients were reactive in the ELISA, and 20% of these could be confirmed by immunoblot. Therefore, the prevalence for B. burgdorferi antibodies in sarcoidosis patients was 1.6%. This result did not differ significantly from the prevalence of B. burgdorferi antibodies in 1,000 regular blood donors of the city of Hamburg (7% reactive in the ELISA, 38% confirmed via immunoblot, prevalence 2.7%). The hypothesis of causality between a B. burgdorferi infection and sarcoidosis cannot be confirmed by this data. ER -