TY - T1的单侧肺移植后肺血液动力学终末期肺实质疾病JF -欧洲呼吸杂志》乔欧元和J SP - 2007 LP - 2011 - 10.1183 / 09031936.96.09102007六世- 9 - 10盟盟- O Bjortuft盟Simonsen——或者Geiran盟——詹贫瘠高原非盟- E Skovlund盟J央行Y1 - 1996/10/01 UR - //www.qdcxjkg.com/content/9/10/2007.abstract N2 -在未来的研究中,我们研究了单侧肺移植的效果(SLT)肺血液动力学和肺动脉高压(PH)之间的关系和灌注的分数的移植患者终末期肺实质疾病。二十四SLT接受者都包括在这项研究中,19日与慢性阻塞性肺疾病(COPD),两个与结节病和三个fibrosing牙槽炎。肺量测定法,测定动脉血气值,灌注显像和右心导管进行之前,移植后6、12和24个月。Patients with a mean pulmonary artery pressure (Ppa) > or = 20 mmHg before transplantation were defined as having PH (PH group, 15 patients) and the remainder (9 patients) constituted the non-PH group. In the PH group, Ppa and pulmonary vascular resistance (PVR) were significantly decreased after transplantation: 28 +/- 2 to 18 +/- 1 mmHg and 288 to 161 +/- 11 dyne.s-1.cm-5, respectively (mean +/- SEM). In the non-PH group, the haemodynamic parameters were unchanged after transplantation. Over the 2 year follow-up period, no significant change was found in Ppa and PVR, nor any difference between the PH and non-PH group. There was no significant difference between the two groups in terms of pulmonary perfusion to the graft. In conclusion, patients with pulmonary hypertension obtain pulmonary haemodynamics within the normal range after single-lung transplantation. Presence or absence of pulmonary hypertension before transplantation does not influence perfusion to the graft. These findings persist up to 2 yrs, despite the coexistence of an "end-stage" native lung and a lung transplant. ER -