RT期刊文章SR电子T1肺部细胞肉芽肿病（组织细胞增多症X）中生存的决定因素。Groupe d'Etude en Pathologie interstitielle de la Societe de Pathologie thoracique du nord jf Nord JF欧洲呼吸杂志Jo Eur Respir J FD欧洲呼吸学会SP 2002 OP 188bet官网地址2006 VO 9 IS 10 A1 DELOBBE，A1 DURIEU，A1 DURIEU，J A1 DUHAMER，J A1 DUHAMER，A A1 WALLAERT，A A1 WALLAERT，A A1 WALLAERT，A A1 WALLAERT，A A1 WALLAERT，A A1 WALLAERT，A A1 WALLAERT，AB yr 1996 ul //www.qdcxjkg.com/content/9/9/10/2002.abstract ab ab thrables肺兰格汉的细胞肉芽肿病（肺LCG）是可变的，难以预测，并且从自发性呼吸道缓解范围从不足和死亡。为了确定生存的决定因素，我们对45例肺LCG患者进行了生存分析。患者年龄28岁+/- 10岁（平均+/- SD）（范围12-62岁），32名男性和13名女性，几乎完全吸烟者（96％），在诊断时出现78％的症状。通过肺活检对25例（56％）和支气管肺泡灌洗（BAL）分析（44％）进行诊断。诊断后，患者的中位期为6年（范围为1 - 29年）。在观察期间，有33名（73％）患者幸存（中位随访期= 5.8岁；范围，1-29岁），12岁（27％）死亡或接受了肺移植（中位随访期= 8.4年）;范围1.4-16.1年）。中位生存约为13年。 A univariate analysis demonstrated that diminished survival was significantly associated with: an older age at diagnosis (p = 0.0001); a lower forced expiratory volume in one second/forced vital capacity (FEV1/FVC) ratio at diagnosis (p = 0.005); a higher residual volume/total lung volume (RV/TLC) ratio at diagnosis (p = 0.02); and steroid therapy during follow-up (p = 0.03). Additional predictive information on mortality was: age > 26 yrs (sensitivity 83%, specificity 64%); FEV1/FVC ratio < 0.66 (sensitivity 75%, specificity 86%); and a RV/TLC ratio > 0.33 (sensitivity 75%, specificity 63%). In multivariate Cox analysis, the combination of factors which gave the best prognostic value was FEV1/FVC ratio and age (p < 0.01). The present findings suggest that adverse prognosis factors at diagnosis in pulmonary Langerhans' cell granulomatosis include older age, lower FEV1/FVC ratio and higher RV/TLC ratio, with additional predictive information on mortality if aged > 26 yrs, FEV1/FVC ratio < 0.66, and RV/TLC ratio > 0.33.