TY - JOUR T1 - Obstructive sleep apnoea and 5-year cognitive decline in the elderly JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01621-2022 VL - 61 IS - 4 SP - 2201621 AU - Marchi, Nicola Andrea AU - Solelhac, Geoffroy AU - Berger, Mathieu AU - Haba-Rubio, José AU - Gosselin, Nadia AU - Vollenweider, Peter AU - Marques-Vidal, Pedro AU - Popp, Julius AU - von Gunten, Armin AU - Preisig, Martin AU - Draganski, Bogdan AU - Heinzer, Raphael Y1 - 2023/04/01 UR - //www.qdcxjkg.com/content/61/4/2201621.abstract N2 - Background The relationship between obstructive sleep apnoea (OSA) and cognitive decline remains controversial, especially in the elderly population.HypnoLaus研究数据评估OSA和纵向认知变化关联社区居住长者样本。Methods初级结果为认知分数逐年变化年龄、性别和apoloteinE4(ApoE4)状态的调节效果也得到了审查。男性42.5%)睡眠期间低值外围氧饱和度(SpO2)与微量脑状态考试下降幅度较大相关联(B=-0.12,p=0.004),Stroop测试条件1(B=0.53,p=0.002)和免费并包选择提醒测试延迟召回时间(B=-0.05,p=0.008)。SpO2 <90%与Stroop测试条件1下降幅度较大相关联(B=0.47,p=0.006)。温和分析显示a-hyponoea索引和氧分解索引与全局认知功能、处理速度和运算函数下降幅度较大相关联