TY -的T1 -我们如何加强保护immunity to COVID-19 in lung transplant recipients? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01723-2022 VL - 61 IS - 1 SP - 2201723 AU - David W.J. Griffin AU - James H. McMahon Y1 - 2023/01/01 UR - //www.qdcxjkg.com/content/61/1/2201723.abstract N2 - The COVID-19 pandemic has had a multifaceted impact on the care and health of immunocompromised individuals, including solid organ transplant (SOT) recipients [1]. Lung transplant recipients are particularly vulnerable, with rates of severe disease, hospitalisation and death due to COVID-19 exceeding those of the immunocompetent population and other transplant groups [2]. However, the lung transplant group is heterogeneous and intersects with other populations at risk of severe disease, including the elderly, and those with intercurrent comorbid disease and other immunocompromising conditions [2]. Although SOT recipients were relatively underrepresented in early waves of the COVID-19 pandemic due to behaviour modification, physical distancing and masks, a growing number are now experiencing COVID-19 infection. Prevention of COVID-19 in this group is increasingly important. Given immunisation is a key component of COVID-19 prevention, there is a pressing need to better understand vaccine responses in lung transplant recipients.A more nuanced understanding of the immunological factors protecting lung transplant recipients from COVID-19 infection and severe disease are urgently required, including the roles for additional booster doses and immunosuppression modification https://bit.ly/3C8dOlq ER -