AU - de Zwart, Auke E.S. AU - Riezebos-Brilman, Annelies AU - Lunter, Gerton A. AU - Neerken, Ewald C.U. AU - van Leer-Buter, Coretta C. AU - Alffenaar, Jan-Willem C. AU - van Gemert, Anna P. AU - Erasmus, Michiel E. AU - Gan, Christiaan T. AU - Kerstjens, Huib A.M.AU - Vonk, Judith M. AU - Verschuuren, Erik A.M.TI - COVID-19社会距离措施对肺移植受者的影响:整体呼吸道病毒感染的下降与肺功能的稳定相关AID - 10.1183/13993003.00085-2022 DP -2022 01年11月TA -欧洲呼吸杂志PG - 2200085 VI - 60 IP - 5 4099 - //www.qdcxjkg.com/content/60/5/2200085.short 4100 - //www.qdcxjkg.com/content/60/5/2200085.full SO - Eur Respir J2022 01年11月;60 AB -背景2019冠状病毒病(COVID-19)社会距离措施导致非COVID-19呼吸道病毒感染急剧下降，为研究其对肺移植受者(ltr) 1 s年度用力呼气量(FEV1)下降、提示感染的暂时性肺功能下降(TDLF)发作和慢性肺异体移植物功能障碍(CLAD)的影响提供了独特的机会。方法包括2009年至2020年4月在荷兰格罗宁根大学医学中心移植的ltr的所有FEV1值。年度FEV1变化是通过对社交距离前(2009-2020年)和采取社交距离措施的年份(2020-2021年)的单独估计来估计的。患者按TDLF频率(频繁/不频繁)分组。呼吸道病毒循环是根据每周全医院呼吸道病毒感染率得出的。评估TDLF频率和呼吸道病毒循环对效果的影响。随着时间的推移，分析了CLAD和TDLF率。结果共纳入479个ltr(12 775个FEV1值)。 Pre-social distancing annual change in FEV1 was −114 (95% CI −133– −94) mL, while during social distancing FEV1 did not decline: 5 (95% CI −38–48) mL (difference pre-social distancing versus during social distancing: p<0.001). The frequent TDLF subgroup showed faster annual FEV1 decline compared with the infrequent TDLF subgroup (−150 (95% CI −181– −120) versus −90 (95% CI −115– −65) mL; p=0.003). During social distancing, we found significantly lower odds for any TDLF (OR 0.53, 95% CI 0.33–0.85; p=0.008) and severe TDLF (OR 0.34, 0.16–0.71; p=0.005) as well as lower CLAD incidence (OR 0.53, 95% CI 0.27–1.02; p=0.060). Effect modification by respiratory virus circulation indicated a significant association between TDLF/CLAD and respiratory viruses.Conclusions During COVID-19 social distancing the strong reduction in respiratory virus circulation coincided with markedly less FEV1 decline, fewer episodes of TDLF and possibly less CLAD. Effect modification by respiratory virus circulation suggests an important role for respiratory viruses in lung function decline in LTRs.Reduction in respiratory virus circulation during social distancing was associated with stabilisation of lung function in lung transplant recipients, suggesting a more important role for these infections in lung function decline than previously thought https://bit.ly/3tWuxDO